Abstract
Human platelet membranes were solubilized with the zwitterionic detergent CHAPS (3-[3-(cholamidopropyl)-dimethylammonio]-1-propanesulfonate) and the solubilized extract subjected to gel filtration. Binding of the adenosine receptor agonist [3H]NECA (5'-N-ethylcarboxamidoadenosine) was measured to the eluted fractions. Two [3H]NECA binding peaks were eluted, the first of them with the void volume. This first peak represented between 10% and 25% of the [3H]NECA binding activity eluted from the column. It bound [3H]NECA in a reversible, saturable and GTP-dependent manner with an affinity of 46 nmol/l and a binding capacity of 510 fmol/mg protein. Various adenosine receptor ligands competed for the binding of [3H]NECA to the first peak with a pharmacological profile characteristic for the A2 adenosine receptor as determined from adenylate cyclase experiments. In contrast, most adenosine receptor ligands did not compete for [3H]NECA binding to the second, major peak. These results suggest that a solubilized A2 receptor-Gs protein complex of human platelets can be separated from other [3H]NECA binding sites by gel filtration. This allows reliable radioligand binding studies of the A2 adenosine receptor of human platelets.
MeSH Terms
Adenosine/analogs & derivatives,metabolism
Adenosine-5'-(N-ethylcarboxamide)
Binding Sites
Blood Platelets/metabolism
Cholic Acids
Chromatography, Gel
Humans
Radioligand Assay
Receptors, Adrenergic, alpha/isolation & purification
Solubility
Chemicals
Cholic Acids
Receptors, Adrenergic, alpha
Adenosine-5'-(N-ethylcarboxamide)
Adenosine
3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Lohse M J
Pharmakologisches Institut, Universität Heidelberg, Federal Republic of Germany.
Elger B
Lindenborn-Fotinos J
Klotz K N
Schwabe U
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