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PMID: 2831722 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Detection of type 1 insulinlike growth factor (IGF) receptors in Wilms' tumors.

The American journal of pathology ·Vol. 130 ·No. 3 ·1988-03-00 ·Pages 431-5

Gansler T, Allen KD, Burant CF, Inabnett T, Scott A, Buse MG, Sens DA, Garvin AJ

Abstract

Insulinlike growth factors (IGFs) are peptide hormones that regulate proliferation and differentiation of several types of normal and neoplastic cells. Recent studies of Wilms' tumor, a childhood kidney neoplasm, have detected increased expression of IGF-2 mRNA and protein. The present report describes detection of Type 1 IGF receptors in specimens of Wilms' tumor and adjacent nonneoplastic kidney tissue. These receptors recognize both IGF-1 and IGF-2, and binding of either peptide activates endogenous tyrosine kinase activity of the Type 1 IGF receptor beta subunit. These data indicate that Wilms' tumors contain receptors that recognize and respond to exogenous IGF in vitro, and that autocrine IGF production might contribute to the increased proliferation and abnormal differentiation of these cells in vivo.

MeSH Terms
Electrophoresis, Polyacrylamide Gel Humans Insulin-Like Growth Factor I/metabolism Insulin-Like Growth Factor II/metabolism Kidney/analysis Phosphorylation Protein-Tyrosine Kinases/analysis Receptor, Insulin/analysis Receptors, Somatomedin Wilms Tumor/analysis
Chemicals
Receptors, Somatomedin Insulin-Like Growth Factor I Insulin-Like Growth Factor II Protein-Tyrosine Kinases Receptor, Insulin
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Gansler T
Department of Pathology, Medical University of South Carolina, Charleston 29425.
Allen K D
Burant C F
Inabnett T
Scott A
Buse M G
Sens D A
Garvin A J
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1988-03-00
Pages
431-5
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1880681
Subset
IM
Grants
NCI NIH HHS · CA37887 · United States
NIDDK NIH HHS · DK02001 · United States
External Links
PubMed source PMC Full Text View journal details
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