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PMID: 2821892 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Treatment of Clostridium difficile colitis in hamsters with a lipopeptide antibiotic, LY146032.

Antimicrobial agents and chemotherapy ·Vol. 31 ·No. 7 ·1987-07-00 ·Pages 1135-6

Dong MY, Chang TW, Gorbach SL

Abstract

LY146032, an acidic lipopeptide antibiotic which inhibits the biosynthesis of cell wall peptidoglycan, was found to be effective in delaying death in a hamster model of pseudomembranous colitis. A dose of 0.05 mg/day was effective. The equivalent protection with vancomycin required a dose 100-fold higher, i.e., 5 mg/day.

MeSH Terms
Animals Anti-Bacterial Agents/therapeutic use Clindamycin/adverse effects Cricetinae Daptomycin Disease Models, Animal Enterocolitis, Pseudomembranous/drug therapy Male Mesocricetus Peptides/therapeutic use Vancomycin/therapeutic use
Chemicals
Anti-Bacterial Agents Peptides Clindamycin Vancomycin Daptomycin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dong M Y
Department of Community Health, Tufts University School of Medicine, Boston, Massachusetts 02111.
Chang T W
Gorbach S L
References (4)
4 references, click to expand
  1. The protective effect of vancomycin on clindamycin-induced colitis in hamsters.
    Johns Hopkins Med J. 1977 Oct;141(4):183-92 PMID: 909214
  2. Effect of calcium on in vitro activity of LY146032 against Clostridium difficile.
    Antimicrob Agents Chemother. 1987 Mar;31(3):461-2 PMID: 3034146
  3. Neutralization of Clostridium difficile toxin by Clostridium sordellii antitoxins.
    Infect Immun. 1978 Nov;22(2):418-22 PMID: 730363
  4. Clindamycin-associated colitis due to a toxin-producing species of Clostridium in hamsters.
    J Infect Dis. 1977 Nov;136(5):701-5 PMID: 915343
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.31.7.1135
Published
1987-07-00
Pages
1135-6
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC174884
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.31.7.1135 PMC Full Text View journal details
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