Structure and mobilization of an ampicillin and gentamicin resistance determinant.

Antimicrobial agents and chemotherapy ·Vol. 31 ·No. 8 ·1987-08-00 ·Pages 1266-70

Martin C, Gomez-Lus R, Ortiz JM, Garcia-Lobo JM

Abstract

A DNA segment originally found in an epidemic plasmid of Escherichia coli encoding an aminoglycoside-(3)-N-acetyltransferase gene (aacC5) and a TEM-type beta-lactamase gene was characterized. The two genes were adjacent and constituted a single transcriptional unit. In addition, these genes were simultaneously mobilized through the action of an insertion sequence related to IS26, IS140, and IS15-delta. This DNA segment is a composite transposon which has been called Tn2922.

MeSH Terms

Ampicillin/pharmacology Base Sequence Culture Media DNA Transposable Elements DNA, Bacterial/analysis,isolation & purification,ultrastructure Genes, Bacterial Gentamicins/pharmacology Microscopy, Electron Mutation Penicillin Resistance/genetics Plasmids Transcription, Genetic

Chemicals

Culture Media DNA Transposable Elements DNA, Bacterial Gentamicins Ampicillin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Martin C

Gomez-Lus R

Ortiz J M

Garcia-Lobo J M

References (18)

18 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.31.8.1266

Published

1987-08-00

Pages

1266-70

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC174916

Subset

External Links

PubMed source DOI: 10.1128/AAC.31.8.1266 PMC Full Text View journal details

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Structure and mobilization of an ampicillin and gentamicin resistance determinant.

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