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PMID: 28166865 Published · epublish English Journal Article Research Support, Non-U.S. Gov't

Generation of shape complexity through tissue conflict resolution.

eLife ·Vol. 6 ·2017-00-07

Rebocho AB, Southam P, Kennaway JR, Bangham JA, Coen E

Abstract

Out-of-plane tissue deformations are key morphogenetic events during plant and animal development that generate 3D shapes, such as flowers or limbs. However, the mechanisms by which spatiotemporal patterns of gene expression modify cellular behaviours to generate such deformations remain to be established. We use the Snapdragon flower as a model system to address this problem. Combining cellular analysis with tissue-level modelling, we show that an orthogonal pattern of growth orientations plays a key role in generating out-of-plane deformations. This growth pattern is most likely oriented by a polarity field, highlighted by PIN1 protein localisation, and is modulated by dorsoventral gene activity. The orthogonal growth pattern interacts with other patterns of differential growth to create tissue conflicts that shape the flower. Similar shape changes can be generated by contraction as well as growth, suggesting tissue conflict resolution provides a flexible morphogenetic mechanism for generating shape diversity in plants and animals.

Keywords
Antirrhinum majus PIN1 polarity developmental biology morphogenesis orthognal cell files out-of-plane deformations plant biology stem cells tissue conflict resolution
MeSH Terms
Antirrhinum/genetics,growth & development Flowers/genetics,growth & development Gene Expression Regulation, Developmental Morphogenesis
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Rebocho Alexandra B
Department of Cell and Developmental Biology, John Innes Centre, Norwich, England.
Southam Paul
Department of Cell and Developmental Biology, John Innes Centre, Norwich, England.
Kennaway J Richard
Department of Cell and Developmental Biology, John Innes Centre, Norwich, England.
Bangham J Andrew
School of Computational Sciences, University of East Anglia, Norwich, England.
Coen Enrico ORCID
Department of Cell and Developmental Biology, John Innes Centre, Norwich, England.
Conflict of Interest

The authors declare that no competing interests exist.

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Article Info
Journal
eLife
Abbr.
Elife
ISSN
2050-084X
DOI
10.7554/eLife.20156
Published
2017-00-07
Epub
2017-00-07
Language
English
Region
England
NLM ID
101579614
PMCID
PMC5295819
Subset
IM
Grants
Biotechnology and Biological Sciences Research Council · BBS/E/J/00000152 · United Kingdom
Biotechnology and Biological Sciences Research Council · BBS/E/J/000PR9773 · United Kingdom
Biotechnology and Biological Sciences Research Council · BB/J004588/1 · United Kingdom
Corrections
CommentIn
PMID: 28441567
External Links
PubMed source DOI: 10.7554/eLife.20156 PMC Full Text View journal details
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