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题目:: Single-Cell Analysis Uncovers Clonal Acinar Cell Heterogeneity in the Adult Pancreas.
作者:: Wollny(Damian),Zhao(Sheng),Everlien(Isabelle),Lun(Xiaokang),Brunken(Jan),Brüne(Daniel),Ziebell(Frederik),Tabansky(Inna),Weichert(Wilko),Marciniak-Czochra(Anna),Martin-Villalba(Ana)
状态:: 发布时间2016-12-07 , 更新时间 2016-12-08
期刊:: Dev Cell
摘要:: Acinar cells make up the majority of all cells in the pancreas, yet the source of new acinar cells during homeostasis remains unknown. Using multicolor lineage-tracing and organoid-formation assays, we identified the presence of a progenitor-like acinar cell subpopulation. These cells have long-term self-renewal capacity, albeit in a unipotent fashion. We further demonstrate that binuclear acinar cells are terminally differentiated acinar cells. Transcriptome analysis of single acinar cells revealed the existence of a minor population of cells expressing progenitor markers. Interestingly, a gain of the identified markers accompanied by a transient gain of proliferation was observed following chemically induced pancreatitis. Altogether, our study identifies a functionally and molecularly distinct acinar subpopulation and thus transforms our understanding of the acinar cell compartment as a pool of equipotent secretory cells.
语言:: eng
DOI:: 10.1016/j.devcel.2016.10.002

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