Borna disease, a progressive meningoencephalomyelitis as a model for CD4+ T cell-mediated immunopathology in the brain.

The Journal of experimental medicine ·Vol. 170 ·No. 3 ·1989-09-01 ·Pages 1045-50

Richt JA, Stitz L, Wekerle H, Rott R

Abstract

A homogeneous T cell line NM1 with Borna disease (BD) virus reactivity could be established. The NM1 cells have been characterized as CD4+ T cells. Adoptive transfer revealed that this MHC class II-restricted immune cell is responsible for the immunopathological effect leading to BD, a progressive meningoencephalomyelitis.

MeSH Terms

Animals Antigens, Differentiation, T-Lymphocyte/analysis Borna Disease/immunology Borna disease virus/immunology Disease Models, Animal Meningoencephalitis/immunology Rats Rats, Inbred Lew T-Lymphocytes/immunology

Chemicals

Antigens, Differentiation, T-Lymphocyte

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Richt J A

Institut für Virologie, Justus-Liebig-Universität Giessen, Federal Republic of Germany.

Stitz L

Wekerle H

Rott R

References (11)

11 references, click to expand

Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy.
Lancet. 1971 Jun 19;1(7712):1257-60 PMID: 4104715
Further studies of a simian virus 40-like virus isolated from human brain.
J Virol. 1972 Jul;10(1):147-9 PMID: 4114323
Replication of Borna disease virus in cell cultures.
Med Microbiol Immunol. 1980;168(3):153-8 PMID: 6772932
The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis.
Eur J Immunol. 1981 Mar;11(3):195-9 PMID: 6165588
Behavioral disease in rats caused by immunopathological responses to persistent borna virus in the brain.
Science. 1983 Jun 24;220(4604):1401-3 PMID: 6602380
Borna disease: a persistent virus infection of the central nervous system.
Prog Med Virol. 1988;35:107-51 PMID: 3051132
Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders.
Science. 1985 May 10;228(4700):755-6 PMID: 3922055
Purification and properties of an intranuclear virus-specific antigen from tissue infected with Borna disease virus.
J Gen Virol. 1986 Feb;67 ( Pt 2):235-41 PMID: 3080548
Cytoimmunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system.
Nature. 1986 May 15-21;321(6067):239-43 PMID: 3086743
Pathogenesis of infection with human immunodeficiency virus.
N Engl J Med. 1987 Jul 30;317(5):278-86 PMID: 3299092
Functions of rat T-lymphocyte subsets isolated by means of monoclonal antibodies.
Immunol Rev. 1983;74:57-82 PMID: 6226588

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.170.3.1045

Published

1989-09-01

Pages

1045-50

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2189432

Subset

External Links

PubMed source DOI: 10.1084/jem.170.3.1045 PMC Full Text View journal details

Analysis Services

Borna disease, a progressive meningoencephalomyelitis as a model for CD4+ T cell-mediated immunopathology in the brain.

Contact

WeChat Official Account