Abstract
The penicillin-binding protein (PBP) profile of Haemophilus ducreyi was determined by a whole-cell-labeling assay. Only two major PBPs, of molecular weights 90,000 (PBP 1) and 38,500 (PBP 2), were detected in six of eight strains studied. Competition binding experiments and the attendant morphological effects suggested that PBP 1 was either a functional amalgamation or a lack of resolution of two proteins equivalent to PBPs 1 and 3 of Escherichia coli.
MeSH Terms
Anti-Bacterial Agents/pharmacology
Bacterial Proteins
Carrier Proteins/metabolism
Haemophilus ducreyi/drug effects,metabolism
Hexosyltransferases
Lactams
Molecular Weight
Muramoylpentapeptide Carboxypeptidase/metabolism
Penicillin Resistance
Penicillin-Binding Proteins
Peptidyl Transferases
Chemicals
Anti-Bacterial Agents
Bacterial Proteins
Carrier Proteins
Lactams
Penicillin-Binding Proteins
Peptidyl Transferases
Hexosyltransferases
Muramoylpentapeptide Carboxypeptidase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lee B C
Department of Microbiology and Infectious Diseases, University of Calgary, Alberta, Canada.
Bryan L E
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