Home LiteratureArticle Details
PMID: 2788389 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Penicillin-binding proteins of Haemophilus ducreyi.

Antimicrobial agents and chemotherapy ·Vol. 33 ·No. 6 ·1989-06-00 ·Pages 983-6

Lee BC, Bryan LE

Abstract

The penicillin-binding protein (PBP) profile of Haemophilus ducreyi was determined by a whole-cell-labeling assay. Only two major PBPs, of molecular weights 90,000 (PBP 1) and 38,500 (PBP 2), were detected in six of eight strains studied. Competition binding experiments and the attendant morphological effects suggested that PBP 1 was either a functional amalgamation or a lack of resolution of two proteins equivalent to PBPs 1 and 3 of Escherichia coli.

MeSH Terms
Anti-Bacterial Agents/pharmacology Bacterial Proteins Carrier Proteins/metabolism Haemophilus ducreyi/drug effects,metabolism Hexosyltransferases Lactams Molecular Weight Muramoylpentapeptide Carboxypeptidase/metabolism Penicillin Resistance Penicillin-Binding Proteins Peptidyl Transferases
Chemicals
Anti-Bacterial Agents Bacterial Proteins Carrier Proteins Lactams Penicillin-Binding Proteins Peptidyl Transferases Hexosyltransferases Muramoylpentapeptide Carboxypeptidase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lee B C
Department of Microbiology and Infectious Diseases, University of Calgary, Alberta, Canada.
Bryan L E
References (18)
18 references, click to expand
  1. Maturation of the head of bacteriophage T4. I. DNA packaging events.
    J Mol Biol. 1973 Nov 15;80(4):575-99 PMID: 4204102
  2. DNA probe technology for detection of Haemophilus influenzae.
    Mol Cell Probes. 1987 Sep;1(3):221-32 PMID: 3502611
  3. Epidemiologic, clinical, laboratory, and therapeutic features of an urban outbreak of chancroid in North America.
    Rev Infect Dis. 1980 Nov-Dec;2(6):867-79 PMID: 6971469
  4. Genital ulcers in Kenya. Clinical and laboratory study.
    Br J Vener Dis. 1981 Dec;57(6):378-81 PMID: 6799142
  5. Molecular epidemiology of beta-lactamase-specifying plasmids of Haemophilus ducreyi.
    Antimicrob Agents Chemother. 1982 Jun;21(6):857-63 PMID: 6287927
  6. Properties of penicillin-binding proteins in Neisseria gonorrhoeae.
    Antimicrob Agents Chemother. 1981 Feb;19(2):316-22 PMID: 6812490
  7. Penicillin-binding proteins and the mechanism of action of beta-lactam antibiotics.
    Annu Rev Biochem. 1983;52:825-69 PMID: 6351730
  8. Penicillin-binding proteins and the future of beta-lactam antibiotics. The Seventh Fleming Lecture.
    J Gen Microbiol. 1983 May;129(5):1247-60 PMID: 6352855
  9. Mechanism of resistance of an ampicillin-resistant, beta-lactamase-negative clinical isolate of Haemophilus influenzae type b to beta-lactam antibiotics.
    Antimicrob Agents Chemother. 1984 Jun;25(6):747-53 PMID: 6611136
  10. An outbreak of chancroid in Orange County, California: descriptive epidemiology and disease-control measures.
    J Infect Dis. 1985 May;151(5):840-4 PMID: 2985711
  11. Mode of action of beta-lactam antibiotics.
    Pharmacol Ther. 1985;27(1):1-35 PMID: 3889939
  12. AIDS virus infection in Nairobi prostitutes. Spread of the epidemic to East Africa.
    N Engl J Med. 1986 Feb 13;314(7):414-8 PMID: 3484804
  13. Newly made enzymes determine ongoing cell wall synthesis and the antibacterial effects of cell wall synthesis inhibitors.
    J Bacteriol. 1986 Aug;167(2):535-43 PMID: 3525515
  14. Activity of penicillin-binding protein 3 from Escherichia coli.
    J Bacteriol. 1986 Oct;168(1):199-206 PMID: 3531167
  15. Two distinct transpeptidation reactions during murein synthesis in Escherichia coli.
    J Bacteriol. 1987 Jul;169(7):3099-103 PMID: 3298212
  16. Chancroid in the United States. Reestablishment of an old disease.
    JAMA. 1987 Dec 11;258(22):3265-8 PMID: 2824868
  17. Haemophilus influenzae penicillin-binding proteins 1a and 3 possess distinct and opposite temperature-modulated penicillin-binding activities.
    Antimicrob Agents Chemother. 1988 Apr;32(4):498-502 PMID: 3259855
  18. Penicillin-binding proteins in bacteria.
    Antimicrob Agents Chemother. 1980 Jul;18(1):148-57 PMID: 7416741
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
Published
1989-06-00
Pages
983-6
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC284271
Subset
IM
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com