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PMID: 2787806 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Infiltration of immune T cells in the brain of mice with herpes simplex virus-induced encephalitis.

Journal of neuroimmunology ·Vol. 23 ·No. 3 ·1989-08-00 ·Pages 195-201

Chan WL, Javanovic T, Lukic ML

Abstract

Herpes simplex virus (HSV) infection of mice can induce viral encephalitis. Using two-fluorochrome immunofluorescence, our present study shows that though there is extensive myelin loss and necrosis in the brain stem of mice with HSV encephalitis, only some oligodendrocytes, astrocytes and microglial cells are infected. T cells that express CD4 or CD8 and a large number of CD4+, F4/80+ macrophages are present in perivascular infiltrates close to and in contact with HSV-infected cells in areas of massive myelin loss. These findings suggest that the resultant infiltration of immune cells into the brain during HSV-1 infection may cause as much damage as the virus itself.

MeSH Terms
Animals Antibodies, Monoclonal Antibodies, Viral/analysis Brain/immunology,microbiology,pathology Cell Movement Encephalitis/etiology,pathology Herpes Simplex Male Mice Mice, Inbred CBA Myelin Sheath/ultrastructure T-Lymphocytes/pathology,physiology
Chemicals
Antibodies, Monoclonal Antibodies, Viral
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Chan W L
Department of Microbiology, Guy's Medical School, London, U.K.
Javanovic T
Lukic M L
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Article Info
Journal
Journal of neuroimmunology
Abbr.
J Neuroimmunol
ISSN
0165-5728
DOI
10.1016/0165-5728(89)90051-9
Published
1989-08-00
Pages
195-201
Language
English
Region
Netherlands
NLM ID
8109498
PMCID
PMC7119877
Subset
IM
External Links
PubMed source DOI: 10.1016/0165-5728(89)90051-9 PMC Full Text View journal details
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