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题目:: Intercellular Coupling of the Cell Cycle and Circadian Clock in Adult Stem Cell Culture.
作者:: Matsu-Ura(Toru),Dovzhenok(Andrey),Aihara(Eitaro),Rood(Jill),Le(Hung),Ren(Yan),Rosselot(Andrew E),Zhang(Tongli),Lee(Choogon),Obrietan(Karl),Montrose(Marshall H),Lim(Sookkyung),Moore(Sean R),Hong(Christian I)
状态:: 发布时间2016-11-21 , 更新时间 2016-12-02
期刊:: Mol Cell
摘要:: Circadian clock-gated cell division cycles are observed from cyanobacteria to mammals via intracellular molecular connections between these two oscillators. Here we demonstrate WNT-mediated intercellular coupling between the cell cycle and circadian clock in 3D murine intestinal organoids (enteroids). The circadian clock gates a population of cells with heterogeneous cell-cycle times that emerge as 12-hr synchronized cell division cycles. Remarkably, we observe reduced-amplitude oscillations of circadian rhythms in intestinal stem cells and progenitor cells, indicating an intercellular signal arising from differentiated cells governing circadian clock-dependent synchronized cell division cycles. Stochastic simulations and experimental validations reveal Paneth cell-secreted WNT as the key intercellular coupling component linking the circadian clock and cell cycle in enteroids.
语言:: eng
DOI:: 10.1016/j.molcel.2016.10.015

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