| GeneLibs

题目:: Characterization of activation of a partially defective B cell subpopulation with immunocompetence restricted to IgM and IgA.
作者:: Nakaniwa(H),Kajikawa(T),Bito(Y)
状态:: 发布时间1989-06-23 , 更新时间 2013-11-21
期刊:: Microbiol Immunol
摘要:: A B-cell subpopulation (BM-A cell) responding to an antigen with the production of IgM and IgA plaque-forming cells but not of IgG plaque-forming cells was isolated from neonatally bursectomized chickens and was examined for the mode of activation by B-cell mitogens. The BM-A cells did not elevate both glucose consumption and protein synthesis with the B-cell mitogens, in striking contrast to normal B cells. The BM-A cells were also not activated by an activator of protein kinase C, phorbol myristate acetate. Both anti-Ig and a calcium ionophore, A23187, however, primed the BM-A cells to increase intracellular free calcium ion as well as normal B cells. From these results it is conceived that the lack of protein kinase C activation may be responsible for the failure of activation of BM-A cells.
语言:: eng
DOI:

文献库文献相关信息