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PMID: 27854360 Published · ppublish English Journal Article

Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2016 update (ACMG SF v2.0): a policy statement of the American College of Medical Genetics and Genomics.

Kalia SS, Adelman K, Bale SJ, Chung WK, Eng C, Evans JP, Herman GE, Hufnagel SB, Klein TE, Korf BR, McKelvey KD, Ormond KE, Richards CS, Vlangos CN, Watson M, Martin CL, Miller DT

Abstract

Disclaimer: These recommendations are designed primarily as an educational resource for medical geneticists and other healthcare providers to help them provide quality medical services. Adherence to these recommendations is completely voluntary and does not necessarily assure a successful medical outcome. These recommendations should not be considered inclusive of all proper procedures and tests or exclusive of other procedures and tests that are reasonably directed toward obtaining the same results. In determining the propriety of any specific procedure or test, the clinician should apply his or her own professional judgment to the specific clinical circumstances presented by the individual patient or specimen. Clinicians are encouraged to document the reasons for the use of a particular procedure or test, whether or not it is in conformance with this statement. Clinicians also are advised to take notice of the date this statement was adopted and to consider other medical and scientific information that becomes available after that date. It also would be prudent to consider whether intellectual property interests may restrict the performance of certain tests and other procedures.To promote standardized reporting of actionable information from clinical genomic sequencing, in 2013, the American College of Medical Genetics and Genomics (ACMG) published a minimum list of genes to be reported as incidental or secondary findings. The goal was to identify and manage risks for selected highly penetrant genetic disorders through established interventions aimed at preventing or significantly reducing morbidity and mortality. The ACMG subsequently established the Secondary Findings Maintenance Working Group to develop a process for curating and updating the list over time. We describe here the new process for accepting and evaluating nominations for updates to the secondary findings list. We also report outcomes from six nominations received in the initial 15 months after the process was implemented. Applying the new process while upholding the core principles of the original policy statement resulted in the addition of four genes and removal of one gene; one gene did not meet criteria for inclusion. The updated secondary findings minimum list includes 59 medically actionable genes recommended for return in clinical genomic sequencing. We discuss future areas of focus, encourage continued input from the medical community, and call for research on the impact of returning genomic secondary findings.Genet Med 19 2, 249-255.

MeSH Terms
Exome/genetics Genetic Testing/standards Genetics, Medical/standards Genome, Human/genetics Genomics Humans Whole Exome Sequencing
Authors & Affiliations
17 authors, click to expand affiliations / ORCID
Kalia Sarah S ORCID
Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Adelman Kathy
Patient advocate, Livermore, California, USA.
Bale Sherri J
GeneDx, Inc., Gaithersburg, Maryland, USA.
Chung Wendy K ORCID
Department of Pediatrics, Columbia University, New York, New York, USA. | Department of Medicine, Columbia University, New York, New York, USA.
Eng Christine
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
Evans James P
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Herman Gail E
Institute for Genomic Medicine, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA.
Hufnagel Sophia B ORCID
Division of Genetics and Metabolism, Children's National Health System, Washington, DC, USA.
Klein Teri E ORCID
Department of Genetics, Stanford University School of Medicine, Palo Alto, California, USA.
Korf Bruce R ORCID
Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
McKelvey Kent D ORCID
Department of Genetics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. | Department of Family Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Ormond Kelly E ORCID
Department of Genetics, Stanford University School of Medicine, Palo Alto, California, USA.
Richards C Sue
Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon, USA.
Vlangos Christopher N ORCID
Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Watson Michael ORCID
American College of Medical Genetics and Genomics, Bethesda, Maryland, USA.
Martin Christa L
Autism & Developmental Medicine Institute, Geisinger Health System, Lewisburg, Pennsylvania, USA.
Miller David T ORCID
Division of Genetics and Genomics, Boston Children's Hospital, Boston, Massachusetts, USA.
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Article Info
Journal
Genetics in medicine : official journal of the American College of Medical Genetics
Abbr.
Genet Med
ISSN
1530-0366
Published
2017-00-00
Epub
2016-00-17
Pages
249-255
Language
English
Region
United States
NLM ID
9815831
Subset
IM
Grants
NIGMS NIH HHS · R24 GM061374 · United States
Corrections
ErratumIn
CommentIn
CommentIn
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