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题目:: A specific defect in the proliferative capacity of B cells from old mice stimulated with autoreactive T cells.
作者:: Nagarkatti(P S),Seth(A),Nagarkatti(M),Muthusamy(N),Rychlik(B),Subbarao(B)
状态:: 发布时间1989-05-23 , 更新时间 2014-11-20
期刊:: Cell Immunol
摘要:: B lymphocytes from aged mice were found to be defective in their ability to proliferate in response to stimulation with an autoreactive T cell clone D1.4. The differentiative response leading to antibody secretion was also impaired in the auto D1.4 T cell-stimulated B cells from old mice in comparison to similarly stimulated B cells from young mice. The B cells from old mice were competent in activating the autoreactive T cells such that the T cells were induced to proliferate. The B cell defect appears to be restricted to a certain phase of B cell activation, since old mouse B cells responded to the auto D1.4 T cells by increasing cell surface Ia as well as size, but failed to incorporate tritiated thymidine. The responsiveness to interleukin-4 was found to be similar between B cells from young and old mice. It appeared that the B cells from old mice are specifically defective in progressing from the G0 phase of cell cycle into the S phase when stimulated with the auto D1.4 T cells.
语言:: eng
DOI:

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