| GeneLibs

题目:: Single Cell Isolation and Analysis.
作者:: Hu(Ping),Zhang(Wenhua),Xin(Hongbo),Deng(Glenn)
状态:: 发布时间2016-11-09 , 更新时间 2016-11-10
期刊:: Front Cell Dev Biol
摘要:: Individual cell heterogeneity within a population can be critical to its peculiar function and fate. Subpopulations studies with mixed mutants and wild types may not be as informative regarding which cell responds to which drugs or clinical treatments. Cell to cell differences in RNA transcripts and protein expression can be key to answering questions in cancer, neurobiology, stem cell biology, immunology, and developmental biology. Conventional cell-based assays mainly analyze the average responses from a population of cells, without regarding individual cell phenotypes. To better understand the variations from cell to cell, scientists need to use single cell analyses to provide more detailed information for therapeutic decision making in precision medicine. In this review, we focus on the recent developments in single cell isolation and analysis, which include technologies, analyses and main applications. Here, we summarize the historical background, limitations, applications, and potential of single cell isolation technologies.
语言:: eng
DOI:

文献库文献相关信息