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题目:: Alteration of early dendritic cell activation by cancer cell lines predisposes immunosuppression, which cannot be reversed by TLR4 stimulation.
作者:: Kong(Ying Ying),Fuchsberger(Martina),Plebanski(Magdalena),Apostolopoulos(Vasso)
状态:: 发布时间2016-10-31 , 更新时间 2016-12-06
期刊:: Acta Biochim Biophys Sin (Shanghai)
摘要:: Dendritic cells (DCs) have shown promise for use in cancer vaccine and cancer immunotherapy studies. However, we demonstrate that cancer cell lines can negatively interfere with DC generation in granulocyte-macrophage colony-stimulating factor (GM-CSF)-derived cultures, although cancer cells are able to enhance CD80 cell surface activation marker and cytokine secretion. Furthermore, in the presence of cancer cells, GM-CSF-derived DCs are unable to stimulate T-cells. Additional stimulation with toll-like receptor 4 cannot fully reverse the suppressive effect of cancer cells or supernatant. Hence, it is imperative to understand the immunosuppressive effects of cancer on DCs in order for DC-based cancer immunotherapy to be successful.
语言:: eng
DOI:: 10.1093/abbs/gmw102

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