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PMID: 27760335 Published · ppublish English Journal Article Review Research Support, N.I.H., Intramural Comment

Two Bugs a NOD Away from Improving Cancer Therapy Efficacy.

Immunity ·Vol. 45 ·No. 4 ·2016-00-18 ·Pages 714-716

Araya RE, Goldszmid RS

Abstract

It has recently become apparent that the gut microbiota modulates the response to cancer therapy. In this issue of Immunity, Daillère et al. (2016) identified two bacterial species potentiating the anti-tumor effect of cyclophosphamide that are kept in check by the sensor NOD2.

MeSH Terms

Animals Bacteria/metabolism Cyclophosphamide/pharmacology,therapeutic use Gastrointestinal Microbiome/physiology Humans Neoplasms/drug therapy,microbiology Nod2 Signaling Adaptor Protein/metabolism

Chemicals

Nod2 Signaling Adaptor Protein Cyclophosphamide

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Araya Romina E

Inflammatory Cell Dynamics Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

Goldszmid Romina S

Inflammatory Cell Dynamics Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: rgoldszmid@mail.nih.gov.

Article Info

Journal

Immunity

Abbr.

Immunity

ISSN

1097-4180

DOI

10.1016/j.immuni.2016.10.007

rgoldszmid@mail.nih.gov

Published

2016-00-18

Pages

714-716

Language

English

Region

United States

NLM ID

9432918

Subset

Corrections

CommentOn

PMID: 27717798

External Links

PubMed source DOI: 10.1016/j.immuni.2016.10.007 View journal details

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Two Bugs a NOD Away from Improving Cancer Therapy Efficacy.

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