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题目:: Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance.
作者:: Perera(Jason),Zheng(Zhong),Li(Shuyin),Gudjonson(Herman),Kalinina(Olga),Benichou(Jennifer I C),Block(Katharine E),Louzoun(Yoram),Yin(Dengping),Chong(Anita S),Dinner(Aaron R),Weigert(Martin),Huang(Haochu)
状态:: 发布时间2016-10-05 , 更新时间 2016-12-02
期刊:: Cell Rep
摘要:: B cells are unique antigen-presenting cells because their antigen presentation machinery is closely tied to the B cell receptor. Autoreactive thymic B cells can efficiently present cognate self-antigens to mediate CD4 T cell-negative selection. However, the nature of thymocyte-thymic B cell interaction and how this interaction affects the selection of thymic B cell repertoire and, in turn, the T cell repertoire are not well understood. Here we demonstrate that a large percentage of thymic B cells have undergone class switching intrathymically. Thymic B cell class switching requires cognate interaction with specific T cells. Class-switched thymic B cells have a distinct repertoire compared with unswitched thymic B cells or splenic B cells. Particularly, autoreactive B cell specificities preferentially expand in the thymus by undergoing class switching, and these enriched, class-switched autoreactive thymic B cells play an important role in CD4 T cell tolerance.
语言:: eng
DOI:

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