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题目:: CD4Foxp3IL-10 Tr1 Cells Promote Relapse of Diffuse Large B Cell Lymphoma by Enhancing the Survival of Malignant B Cells and Suppressing Antitumor T Cell Immunity.
作者:: Liu(Guozhen),Luan(Jing),Li(Qiang)
状态:: 发布时间2016-10-05 , 更新时间 2016-12-07
期刊:: DNA Cell Biol
摘要:: Diffuse large B cell lymphoma (DLBCL) is a common B cell malignancy. Complete remission can be achieved in most patients by conventional treatment with rituximab and chemotherapy. However, a subset of remission individuals will develop a relapsed disease for obscure reasons. CD4Foxp3IL-10 cell (Tr1) is a novel cell subtype with the capacity to suppress pro-inflammatory responses, but has not been extensively studied in most tumors. In this study, we investigated the potential role of Tr1 cells in DLBCL. We found that compared to that in healthy controls, the frequency of Tr1 cells was significantly increased in DLBCL patients, even during complete remission. Further study showed that these Tr1 cells were enriched in the CD25Foxp3CD49bLAG-3 fraction and could be developed in vitro from naive CD45RA CD4 T cells. To examine the effect of Tr1 upregulation, we cocultured the enriched in vitro-induced Tr1 cells (iTr1) with autologous primary DLBCL cells and CD3 T cells and found that iTr1 cells both enhanced the survival of CD20 DLBCL tumor cells and suppressed the antitumor response of CD3 T cells through the production of IL-10. Furthermore, the frequency of CD4Foxp3IL-10 Tr1 cells in DLBCL patients during complete remission is directly associated with the risk of relapse. Together, these results suggested that Tr1 cells contributed to tumor cell maintenance and may serve as a prognostic marker and therapeutic target.
语言:: eng
DOI:: 10.1089/dna.2016.3399

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