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题目:: Suppression by T cells leads to durable and selective inhibition of B cell effector function.
作者:: Sage(Peter T),Ron-Harel(Noga),Juneja(Vikram R),Sen(Debattama R),Maleri(Seth),Sungnak(Waradon),Kuchroo(Vijay K),Haining(W Nicholas),Chevrier(Nicolas),Haigis(Marcia),Sharpe(Arlene H)
状态:: 发布时间2016-10-03 , 更新时间 2016-11-16
期刊:: Nat Immunol
摘要:: Follicular regulatory T cells (T cells) inhibit follicular helper T cell (T cell)-mediated antibody production. The mechanisms by which T cells exert their key immunoregulatory functions are largely unknown. Here we found that T cells induced a distinct suppressive state in T cells and B cells, in which effector transcriptional signatures were maintained but key effector molecules and metabolic pathways were suppressed. The suppression of B cell antibody production and metabolism by T cells was durable and persisted even in the absence of T cells. This durable suppression was due in part to epigenetic changes. The cytokine IL-21 was able to overcome T cell-mediated suppression and inhibited T cells and stimulated B cells. By determining mechanisms of T cell-mediated suppression, we have identified methods for modulating the function of T cells and antibody production.
语言:: eng
DOI:: 10.1038/ni.3578

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