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题目:: Filamentation protects from amphotericin B-induced programmed cell death via a mechanism involving the yeast metacaspase, .
作者:: Laprade(David J),Brown(Melissa S),McCarthy(Morgan L),Ritch(James J),Austriaco(Nicanor)
状态:: 发布时间2016-09-29 , 更新时间 2016-12-02
期刊:: Microb Cell
摘要:: The budding yeast is one of the most significant fungal pathogens worldwide. It proliferates in two distinct cell types: blastopores and filaments. Only cells that are able to transform from one cell type into the other are virulent in mouse disease models. Programmed cell death is a controlled form of cell suicide that occurs when cells are exposed to fungicidal drugs like amphotericin B and caspofungin, and to other stressful conditions. We now provide evidence that suggests that programmed cell death is cell-type specific in yeast: Filamentous cells are more resistant to amphotericin B- and caspofungin-induced programmed cell death than their blastospore counterparts. Finally, our genetic data suggests that this phenomenon is mediated by a protective mechanism involving the yeast metacaspase, .
语言:: eng
DOI:

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