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PMID: 27669990 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Evolving insights into RNA modifications and their functional diversity in the brain.

Nature neuroscience ·Vol. 19 ·No. 10 ·2016-00-27 ·Pages 1292-8

Nainar S, Marshall PR, Tyler CR, Spitale RC, Bredy TW

Abstract

In this Perspective, we expand the notion of temporal regulation of RNA in the brain and propose that the qualitative nature of RNA and its metabolism, together with RNA abundance, are essential for the molecular mechanisms underlying experience-dependent plasticity. We discuss emerging concepts in the newly burgeoning field of epitranscriptomics, which are predicted to be heavily involved in cognitive function. These include activity-induced RNA modifications, RNA editing, dynamic changes in the secondary structure of RNA, and RNA localization. Each is described with an emphasis on its role in regulating the function of both protein-coding genes, as well as various noncoding regulatory RNAs, and how each might influence learning and memory.

MeSH Terms
Animals Brain/metabolism Cognition Humans Learning Neurons/metabolism RNA/metabolism RNA, Untranslated/metabolism
Chemicals
RNA, Untranslated RNA
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Nainar Sarah
Department of Pharmaceutical Sciences, University of California Irvine, Irvine, California, USA.
Marshall Paul R
Department of Neurobiology and Behavior, University of California Irvine, Irvine, California, USA. | Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, California, USA.
Tyler Christina R
Department of Neurobiology and Behavior, University of California Irvine, Irvine, California, USA. | Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, California, USA.
Spitale Robert C
Department of Pharmaceutical Sciences, University of California Irvine, Irvine, California, USA.
Bredy Timothy W
Department of Neurobiology and Behavior, University of California Irvine, Irvine, California, USA. | Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, California, USA. | Queensland Brain Institute, University of Queensland, Brisbane, Australia.
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Article Info
Journal
Nature neuroscience
Abbr.
Nat Neurosci
ISSN
1546-1726
DOI
10.1038/nn.4378
Published
2016-00-27
Pages
1292-8
Language
English
Region
United States
NLM ID
9809671
PMCID
PMC5068363
Subset
IM
Grants
NIGMS NIH HHS · DP2 GM119164 · United States
NIMH NIH HHS · R01 MH105398 · United States
NIMH NIH HHS · R01 MH109588 · United States
External Links
PubMed source DOI: 10.1038/nn.4378 PMC Full Text View journal details
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