Protein evolution on rugged landscapes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 86 ·No. 16 ·1989-08-00 ·Pages 6191-5

Macken CA, Perelson AS

Abstract

We analyze a mathematical model of protein evolution in which the evolutionary process is viewed as hill-climbing on a random fitness landscape. In studying the structure of such landscapes, we note that a large number of local optima exist, and we calculate the time and number of mutational changes until a protein gets trapped at a local optimum. Such a hill-climbing process may underlie the evolution of antibody molecules by somatic hypermutation.

MeSH Terms

Biological Evolution Mathematics Models, Statistical Probability Proteins/genetics

Chemicals

Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Macken C A

Theoretical Division, Los Alamos National Laboratory, NM 87545.

Perelson A S

References (16)

16 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.86.16.6191

Published

1989-08-00

Pages

6191-5

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC297803

Subset

External Links

PubMed source DOI: 10.1073/pnas.86.16.6191 PMC Full Text View journal details

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Protein evolution on rugged landscapes.

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