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题目:: Spatial distribution of FoxP3+ and CD8+ tumour infiltrating T cells reflects their functional activity.
作者:: Posselt(Rebecca),Erlenbach-Wünsch(Katharina),Haas(Matthias),Jeßberger(Jonas),Büttner-Herold(Maike),Haderlein(Marlen),Hecht(Markus),Hartmann(Arndt),Fietkau(Rainer),Distel(Luitpold)
状态:: 发布时间2016-08-05 , 更新时间 2016-08-05
期刊:: Oncotarget
摘要:: Regulatory and cytotoxic T cells are key players in the host's anticancer immune response. We studied the spatial distribution of FoxP+ and CD8+ cells to identify potential interactions.,In 202 patients 103 pre-radiochemotherapy biopsies and 153 post-radiochemotherapy tumour specimens of advanced rectal cancer were available and an immunohistochemical double staining of FoxP3+ and CD8+ tumour-infiltrating lymphocytes was performed to investigate cell density and cell-to-cell distances.,FoxP3+ cells decreased after radiochemotherapy by a factor of 3 while CD8+ cells remained nearly unchanged. High epithelial (p=0.033) and stromal (p=0.009) FoxP3+ cell density was associated with an improved overall survival. Cell-to-cell distances of randomly distributed cells were simulated and compared to observed cell-to-cell distances. Observed distances shorter than the simulated, random distances were hypothesized to represent FoxP3+ cells actively interacting with CD8+ cells. Epithelial short distances were associated with a favourable prognosis while the opposite was true for the stromal compartment.,The analysis of cell-to-cell distances may offer a tool to predict outcome, maybe by identifying functionally active, interacting infiltrating inflammatory cells in different tumour compartments.
语言:: eng
DOI:: 10.18632/oncotarget.11039

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