Catastrophic neurologic signs due to drug interaction: Tegretol and Darvon.

Surgical neurology ·Vol. 32 ·No. 2 ·1989-08-00 ·Pages 144-51

Oles KS, Mirza W, Penry JK

Abstract

Eight cases of carbamazepine toxicity from interaction with propoxyphene are reported. Serum concentrations of carbamazepine increased up to sixfold. All patients were symptomatic and two were hospitalized. Practitioners prescribing propoxyphene acutely for pain should be aware of this significant interaction.

MeSH Terms

Adult Carbamazepine/adverse effects,blood,metabolism,pharmacokinetics Dextropropoxyphene/adverse effects,metabolism Drug Interactions Female Humans Male Middle Aged Nervous System Diseases/chemically induced

Chemicals

Carbamazepine Dextropropoxyphene

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Oles K S

Department of Neurology, Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103.

Mirza W

Penry J K

Article Info

Journal

Surgical neurology

Abbr.

Surg Neurol

ISSN

0090-3019

DOI

10.1016/0090-3019(89)90203-6

Published

1989-08-00

Pages

144-51

Language

English

Region

United States

NLM ID

0367070

Subset

External Links

PubMed source DOI: 10.1016/0090-3019(89)90203-6 View journal details

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Catastrophic neurologic signs due to drug interaction: Tegretol and Darvon.

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