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题目:: CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles.
作者:: Leong(Yew Ann),Chen(Yaping),Ong(Hong Sheng),Wu(Di),Man(Kevin),Deleage(Claire),Minnich(Martina),Meckiff(Benjamin J),Wei(Yunbo),Hou(Zhaohua),Zotos(Dimitra),Fenix(Kevin A),Atnerkar(Anurag),Preston(Simon),Chipman(Jeffrey G),Beilman(Greg J),Allison(Cody C),Sun(Lei),Wang(Peng),Xu(Jiawei),Toe(Jesse G),Lu(Hao K),Tao(Yong),Palendira(Umaimainthan),Dent(Alexander L),Landay(Alan L),Pellegrini(Marc),Comerford(Iain),McColl(Shaun R),Schacker(Timothy W),Long(Heather M),Estes(Jacob D),Busslinger(Meinrad),Belz(Gabrielle T),Lewin(Sharon R),Kallies(Axel),Yu(Di)
状态:: 发布时间2016-09-21 , 更新时间 2016-09-21
期刊:: Nat Immunol
摘要:: During unresolved infections, some viruses escape immunological control and establish a persistant reservoir in certain cell types, such as human immunodeficiency virus (HIV), which persists in follicular helper T cells (TFH cells), and Epstein-Barr virus (EBV), which persists in B cells. Here we identified a specialized group of cytotoxic T cells (TC cells) that expressed the chemokine receptor CXCR5, selectively entered B cell follicles and eradicated infected TFH cells and B cells. The differentiation of these cells, which we have called 'follicular cytotoxic T cells' (TFC cells), required the transcription factors Bcl6, E2A and TCF-1 but was inhibited by the transcriptional regulators Blimp1, Id2 and Id3. Blimp1 and E2A directly regulated Cxcr5 expression and, together with Bcl6 and TCF-1, formed a transcriptional circuit that guided TFC cell development. The identification of TFC cells has far-reaching implications for the development of strategies to control infections that target B cells and TFH cells and to treat B cell-derived malignancies.
语言:: eng
DOI:: 10.1038/ni.3543

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