Abstract
Forty per cent of patients with mitochondrial myopathies, a diverse group of multisystem diseases predominantly affecting skeletal muscle and the brain, have large deletions of a proportion of muscle mitochondrial DNA (mt DNA). These appeared to be identical in 13 of 28 cases, contained within the region 8286-13595 bp. Analysis of the deletion junction in two cases showed a 13 nucleotide sequence which occurred in the normal genome as a direct repeat flanking the region deleted in the mutant mt DNAs. Mt DNA deletions may arise from recombination or slippage between short sequence repeats during replication.
MeSH Terms
Amino Acid Sequence
Base Sequence
Chromosome Deletion
Cloning, Molecular
DNA, Mitochondrial/genetics,isolation & purification
DNA-Directed DNA Polymerase
Gene Amplification
Humans
Molecular Sequence Data
Muscle Proteins/genetics,isolation & purification
Muscles/metabolism,pathology
Mutation
Neuromuscular Diseases/genetics,metabolism
Repetitive Sequences, Nucleic Acid
Taq Polymerase
Chemicals
DNA, Mitochondrial
Muscle Proteins
Taq Polymerase
DNA-Directed DNA Polymerase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Holt I J
University Department of Clinical Neurology, Institute of Neurology, London, UK.
Harding A E
Morgan-Hughes J A
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