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题目:: Role of CD133 cells in tongue squamous carcinomas: Characteristics of 'stemness' and .
作者:: Wang(Kai),Zhou(Xiao-Kang),Wu(Min),Kang(Fei-Wu),Wang(Zuo-Lin),Zhu(Yan)
状态:: 发布时间2016-07-22 , 更新时间 2016-07-25
期刊:: Oncol Lett
摘要:: The objective of the present study was to determine the 'stemness' characteristics of CD133 cells (harvested from the squamous cell tongue carcinoma Tca-8113 cell line) and to observe the tumourigenicity of the CD133 cells in the bodies of NOD/SCID mice. Single cells from the Tca-8113 cell line were observed for multiplication capacity . The suspending and pelletizing phenomena of Tca-8113 cells were also observed, and the expression of CD133 in squamous cell carcinoma of the tongue was measured. The CD133 cells from the Tca-8113 cell line were purified, and their multiplication capacity and differentiation potency were observed. The NOD/SCID mouse model was established, and the tumourigenicity of the CD133 cells was determined. The Tca-8113 cells were observed to emerge in the form of suspending tumour spheres in squamous cell carcinoma of the tongue. Monoplasts with sustainable multiplication capacity accounted for ~5.32% of the spheres, and 0.95% of the CD133 cells were expressed in squamous cell carcinoma of the tongue, with stronger multiplication capacity and differentiation potency . Stronger tumourigenicity was also observed in the bodies of the NOD/SCID mice. CD133 cells exhibited a multiplication capacity to a certain extent. Overall, the CD133 cells in squamous cell carcinoma of the tongue are characterised by relatively strong tumourigenicity capacity and . To a certain extent, these CD133 cells demonstrate the characteristics of 'stemness'.
语言:: eng
DOI:

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