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题目:: Decreased expression of LncRNA MIR31HG in human bladder cancer.
作者:: He(Anbang),Chen(Zhicong),Mei(Hongbing),Liu(Yuchen)
状态:: 发布时间2016-08-20 , 更新时间 2016-08-20
期刊:: Cancer Biomark
摘要:: In this study, we examined the relationships between the expression level of long non-coding RNA MIR31HG in bladder cancer and the clinical characteristics.,A total of 55 tissue samples from patients with bladder cancer were collected, and the lncRNA MIR31HG levels in cancer, paired non-cancer tissues and BC cell lines were detected by real-time quantitative RT-PCR (qRT-PCR). The relationships between MIR31HG level and the clinical characteristics were evaluated.,MIR31HG expression was remarkably decreased in bladder cancer tissues compared with adjacent noncancerous tissues (P < 0.05). MIR31HG expression was also significantly down-regulated in four bladder cancer cell lines (P < 0.001). Clinicopathologic analysis revealed that MIR31HG expression was negatively associated with TNM stage (P = 0.010), but not with other clinicopathological characteristics.,These findings revealed that MIR31HG may function as a cancer-suppressor gene to participate in the bladder cancer carcinogenesis and development.
语言:: eng
DOI:: 10.3233/CBM-160635

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