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题目:: Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types.
作者:: Kar(Siddhartha P),Beesley(Jonathan),Amin Al Olama(Ali),Michailidou(Kyriaki),Tyrer(Jonathan),Kote-Jarai(ZSofia),Lawrenson(Kate),Lindstrom(Sara),Ramus(Susan J),Thompson(Deborah J),,Kibel(Adam S),Dansonka-Mieszkowska(Agnieszka),Michael(Agnieszka),Dieffenbach(Aida K),Gentry-Maharaj(Aleksandra),Whittemore(Alice S),Wolk(Alicja),Monteiro(Alvaro),Peixoto(Ana),Kierzek(Andrzej),Cox(Angela),Rudolph(Anja),Gonzalez-Neira(Anna),Wu(Anna H),Lindblom(Annika),Swerdlow(Anthony),,,Ziogas(Argyrios),Ekici(Arif B),Burwinkel(Barbara),Karlan(Beth Y),Nordestgaard(Børge G),Blomqvist(Carl),Phelan(Catherine),McLean(Catriona),Pearce(Celeste Leigh),Vachon(Celine),Cybulski(Cezary),Slavov(Chavdar),Stegmaier(Christa),Maier(Christiane),Ambrosone(Christine B),Høgdall(Claus K),Teerlink(Craig C),Kang(Daehee),Tessier(Daniel C),Schaid(Daniel J),Stram(Daniel O),Cramer(Daniel W),Neal(David E),Eccles(Diana),Flesch-Janys(Dieter),Edwards(Digna R Velez),Wokozorczyk(Dominika),Levine(Douglas A),Yannoukakos(Drakoulis),Sawyer(Elinor J),Bandera(Elisa V),Poole(Elizabeth M),Goode(Ellen L),Khusnutdinova(Elza),Høgdall(Estrid),Song(Fengju),Bruinsma(Fiona),Heitz(Florian),Modugno(Francesmary),Hamdy(Freddie C),Wiklund(Fredrik),Giles(Graham G),Olsson(Håkan),Wildiers(Hans),Ulmer(Hans-Ulrich),Pandha(Hardev),Risch(Harvey A),Darabi(Hatef),Salvesen(Helga B),Nevanlinna(Heli),Gronberg(Henrik),Brenner(Hermann),Brauch(Hiltrud),Anton-Culver(Hoda),Song(Honglin),Lim(Hui-Yi),McNeish(Iain),Campbell(Ian),Vergote(Ignace),Gronwald(Jacek),Lubiński(Jan),Stanford(Janet L),Benítez(Javier),Doherty(Jennifer A),Permuth(Jennifer B),Chang-Claude(Jenny),Donovan(Jenny L),Dennis(Joe),Schildkraut(Joellen M),Schleutker(Johanna),Hopper(John L),Kupryjanczyk(Jolanta),Park(Jong Y),Figueroa(Jonine),Clements(Judith A),Knight(Julia A),Peto(Julian),Cunningham(Julie M),Pow-Sang(Julio),Batra(Jyotsna),Czene(Kamila),Lu(Karen H),Herkommer(Kathleen),Khaw(Kay-Tee),,Matsuo(Keitaro),Muir(Kenneth),Offitt(Kenneth),Chen(Kexin),Moysich(Kirsten B),Aittomäki(Kristiina),Odunsi(Kunle),Kiemeney(Lambertus A),Massuger(Leon F A G),Fitzgerald(Liesel M),Cook(Linda S),Cannon-Albright(Lisa),Hooning(Maartje J),Pike(Malcolm C),Bolla(Manjeet K),Luedeke(Manuel),Teixeira(Manuel R),Goodman(Marc T),Schmidt(Marjanka K),Riggan(Marjorie),Aly(Markus),Rossing(Mary Anne),Beckmann(Matthias W),Moisse(Matthieu),Sanderson(Maureen),Southey(Melissa C),Jones(Michael),Lush(Michael),Hildebrandt(Michelle A T),Hou(Ming-Feng),Schoemaker(Minouk J),Garcia-Closas(Montserrat),Bogdanova(Natalia),Rahman(Nazneen),,Le(Nhu D),Orr(Nick),Wentzensen(Nicolas),Pashayan(Nora),Peterlongo(Paolo),Guénel(Pascal),Brennan(Paul),Paulo(Paula),Webb(Penelope M),Broberg(Per),Fasching(Peter A),Devilee(Peter),Wang(Qin),Cai(Qiuyin),Li(Qiyuan),Kaneva(Radka),Butzow(Ralf),Kopperud(Reidun Kristin),Schmutzler(Rita K),Stephenson(Robert A),MacInnis(Robert J),Hoover(Robert N),Winqvist(Robert),Ness(Roberta),Milne(Roger L),Travis(Ruth C),Benlloch(Sara),Olson(Sara H),McDonnell(Shannon K),Tworoger(Shelley S),Maia(Sofia),Berndt(Sonja),Lee(Soo Chin),Teo(Soo-Hwang),Thibodeau(Stephen N),Bojesen(Stig E),Gapstur(Susan M),Kjær(Susanne Krüger),Pejovic(Tanja),Tammela(Teuvo L J),,,Dörk(Thilo),Brüning(Thomas),Wahlfors(Tiina),Key(Tim J),Edwards(Todd L),Menon(Usha),Hamann(Ute),Mitev(Vanio),Kosma(Veli-Matti),Setiawan(Veronica Wendy),Kristensen(Vessela),Arndt(Volker),Vogel(Walther),Zheng(Wei),Sieh(Weiva),Blot(William J),Kluzniak(Wojciech),Shu(Xiao-Ou),Gao(Yu-Tang),Schumacher(Fredrick),Freedman(Matthew L),Berchuck(Andrew),Dunning(Alison M),Simard(Jacques),Haiman(Christopher A),Spurdle(Amanda),Sellers(Thomas A),Hunter(David J),Henderson(Brian E),Kraft(Peter),Chanock(Stephen J),Couch(Fergus J),Hall(Per),Gayther(Simon A),Easton(Douglas F),Chenevix-Trench(Georgia),Eeles(Rosalind),Pharoah(Paul D P),Lambrechts(Diether)
状态:: 发布时间2016-09-02 , 更新时间 2016-12-03
期刊:: Cancer Discov
摘要:: Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these cancers totaling 112,349 cases and 116,421 controls of European ancestry, all together and in pairs, identified at P < 10(-8) seven new cross-cancer loci: three associated with susceptibility to all three cancers (rs17041869/2q13/BCL2L11; rs7937840/11q12/INCENP; rs1469713/19p13/GATAD2A), two breast and ovarian cancer risk loci (rs200182588/9q31/SMC2; rs8037137/15q26/RCCD1), and two breast and prostate cancer risk loci (rs5013329/1p34/NSUN4; rs9375701/6q23/L3MBTL3). Index variants in five additional regions previously associated with only one cancer also showed clear association with a second cancer type. Cell-type-specific expression quantitative trait locus and enhancer-gene interaction annotations suggested target genes with potential cross-cancer roles at the new loci. Pathway analysis revealed significant enrichment of death receptor signaling genes near loci with P < 10(-5) in the three-cancer meta-analysis.,We demonstrate that combining large-scale GWA meta-analysis findings across cancer types can identify completely new risk loci common to breast, ovarian, and prostate cancers. We show that the identification of such cross-cancer risk loci has the potential to shed new light on the shared biology underlying these hormone-related cancers. Cancer Discov; 6(9); 1052-67. ©2016 AACR.This article is highlighted in the In This Issue feature, p. 932.
语言:: eng
DOI:

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