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题目:: Identification of new candidate therapeutic target genes in head and neck squamous cell carcinomas.
作者:: Sablin(Marie-Paule),Dubot(Coraline),Klijanienko(Jerzy),Vacher(Sophie),Ouafi(Lamia),Chemlali(Walid),Caly(Martial),Sastre-Garau(Xavier),Lappartient(Emmanuelle),Mariani(Odette),Rodriguez(José),Jouffroy(Thomas),Girod(Angélique),Calugaru(Valentin),Hoffmann(Caroline),Lidereau(Rosette),Berger(Frédérique),Kamal(Maud),Bieche(Ivan),Le Tourneau(Christophe)
状态:: 发布时间2016-06-24 , 更新时间 2016-11-25
期刊:: Oncotarget
摘要:: We aimed at identifying druggable molecular alterations at the RNA level from untreated HNSCC patients, and assessing their prognostic significance.,We retrieved 96 HNSCC patients who underwent primary surgery. Real-time quantitative RT-PCR was used to analyze a panel of 42 genes coding for major druggable proteins. Univariate and multivariate analyses were performed to assess the prognostic significance of overexpressed genes.,Median age was 56 years [35-78]. Most of patients were men (80%) with a history of alcohol (70.4%) and/or tobacco consumption (72.5%). Twelve patients (12%) were HPV-positive. Most significantly overexpressed genes involved cell cycle regulation (CCND1 [27%], CDK6 [21%]), tyrosine kinase receptors (MET [18%], EGFR [14%]), angiogenesis (PGF [301%], VEGFA [14%]), and immune system (PDL1/CD274 [28%]). PIK3CA expression was an independent prognostic marker, associated with shorter disease-free survival.,We identified druggable overexpressed genes associated with a poor outcome that might be of interest for personalizing treatment of HNSCC patients.
语言:: eng
DOI:: 10.18632/oncotarget.10163

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