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题目:: Distinct recirculation potential of CD69CD103 and CD103 thymic memory CD8 T cells.
作者:: Park(Simone L),Mackay(Laura K),Gebhardt(Thomas)
状态:: 发布时间2016-08-02 , 更新时间 2016-11-22
期刊:: Immunol Cell Biol
摘要:: Tissue-resident memory T (T) cells occupy peripheral and lymphoid tissues where they confer protection against local infection. While epithelial CD8 T cells coexpress CD69 and CD103, CD103 memory cells have been described in various organs and are often presumed non-recirculating based on their expression of CD69. We found that both CD69CD103 and CD69CD103 memory cells populated the thymus upon transfer of CD8 effector T cells into uninfected recipients. Transcriptionally and phenotypically, CD103 thymic cells resembled non-lymphoid T cells, whereas CD69CD103 cells displayed a profile that was more closely related to recirculating cells. Although CD69 was required for optimal CD103 T formation, its expression alone did not identify permanently resident cells, as CD69CD103 cells disappeared from the thymus following antibody-mediated depletion of recirculating cells. Our findings highlight a distinct migration potential of phenotypically divergent thymic CD8 memory T cells and emphasise the inadequacy of CD69 as a marker of tissue residency.
语言:: eng
DOI:: 10.1038/icb.2016.60

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