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PMID: 27307752 Published · epublish English Journal Article

Clinicopathological and prognostic significance of sialyl Lewis X overexpression in patients with cancer: a meta-analysis.

OncoTargets and therapy ·Vol. 9 ·2016-00-00 ·Pages 3113-25

Liang JX, Liang Y, Gao W

Abstract

Many studies have shown that sialyl Lewis X (sLe(X)) is related to cancer prognosis and clinicopathology, but failed to provide conclusive results. We conducted the present meta-analysis to identify the association between sLe(X) overexpression and cancer prognosis. We searched studies in PubMed and Embase databases. Relative risk or hazard ratio with 95% confidence intervals were estimated with the Mantel-Haenszel random-effect method and 29 studies were included. Our meta-analysis showed that sLe(X) overexpression is significantly related to lymphatic invasion, venous invasion, T stage, N stage, M stage, tumor stage, recurrence, and overall survival. In subgroup analysis, we found that cancer type and ethnicity might be two major contributing factors to the possible presence of heterogeneity among the studies. In conclusion, sLe(X) overexpression is associated with tumor metastasis, recurrence, and overall survival in cancer patients, it plays an important role in cancer prognosis.

Keywords
cancer meta-analysis prognosis sialyl Lewis X
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Liang Jin-Xiao
Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China.
Liang Yong
Department of Clinical Medicine, Taizhou University Medical School, Taizhou, People's Republic of China.
Gao Wei
School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang, People's Republic of China.
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Article Info
Journal
OncoTargets and therapy
Abbr.
Onco Targets Ther
ISSN
1178-6930
DOI
10.2147/OTT.S102389
Published
2016-00-00
Epub
2016-00-24
Pages
3113-25
Language
English
Region
New Zealand
NLM ID
101514322
PMCID
PMC4888715
External Links
PubMed source DOI: 10.2147/OTT.S102389 PMC Full Text View journal details
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