Home LiteratureArticle Details
PMID: 2730648 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Caldesmon structure and function: sequence analysis of a 35 kilodalton actin- and calmodulin-binding fragment from the C-terminus of the turkey gizzard protein.

Biochemical and biophysical research communications ·Vol. 160 ·No. 3 ·1989-05-15 ·Pages 1371-8

Leszyk J, Mornet D, Audemard E, Collins JH

Abstract

We have determined the amino acid sequence of a 35 kDa proteolytic fragment ("CaD35") derived from the C-terminus of turkey gizzard caldesmon. This 239-residue peptide contains binding sites for actin and calmodulin. Residues 1-96 of CaD35 comprise "CaD15", an actin-binding subfragment which we previously showed to resemble the tropomyosin-binding segment of troponin T. The remainder of the CaD35 sequence shows no significant similarity to other proteins. Residues 111-128 may form a basic, amphipathic helix which interacts with calmodulin.

MeSH Terms
Actins/metabolism Amino Acid Sequence Amino Acids/analysis Animals Binding Sites Calmodulin/metabolism Calmodulin-Binding Proteins Chromatography, High Pressure Liquid Cyanogen Bromide Gizzard, Avian/analysis Molecular Sequence Data Molecular Weight Peptide Fragments Phosphorylation Protein Conformation Serine Endopeptidases Tropomyosin/metabolism Trypsin Turkeys
Chemicals
Actins Amino Acids Calmodulin Calmodulin-Binding Proteins Peptide Fragments Tropomyosin Serine Endopeptidases glutamyl endopeptidase Trypsin Cyanogen Bromide
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Leszyk J
Department of Biological Chemistry, School of Medicine, University of Maryland, Baltimore 21201.
Mornet D
Audemard E
Collins J H
Article Info
Journal
Biochemical and biophysical research communications
Abbr.
Biochem Biophys Res Commun
ISSN
0006-291X
Published
1989-05-15
Pages
1371-8
Language
English
Region
United States
NLM ID
0372516
Subset
IM
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com