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PMID: 2725677 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor.

Nature ·Vol. 339 ·No. 6224 ·1989-06-08 ·Pages 439-45

Takeshima H, Nishimura S, Matsumoto T, Ishida H, Kangawa K, Minamino N, Matsuo H, Ueda M, Hanaoka M, Hirose T

Abstract

The sequence of 5,037 amino acids composing the ryanodine receptor from rabbit skeletal muscle sarcoplasmic reticulum has been deduced by cloning and sequencing the complementary DNA. The predicted structure suggests that the calcium release channel activity resides in the C-terminal region of the receptor molecule, whereas the remaining portion constitutes the 'foot' structure spanning the junctional gap between the sarcoplasmic reticulum and the transverse tubule.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Calcium Channel Blockers/metabolism Cloning, Molecular DNA/genetics Molecular Sequence Data Muscles/metabolism Protein Conformation RNA, Messenger/genetics Rabbits Receptors, Cholinergic/genetics,isolation & purification Restriction Mapping Ryanodine Receptor Calcium Release Channel Sarcoplasmic Reticulum/physiology,ultrastructure Transcription, Genetic

Chemicals

Calcium Channel Blockers RNA, Messenger Receptors, Cholinergic Ryanodine Receptor Calcium Release Channel DNA

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Takeshima H

Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan.

Nishimura S

Matsumoto T

Ishida H

Kangawa K

Minamino N

Matsuo H

Ueda M

Hanaoka M

Hirose T

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/339439a0

Published

1989-06-08

Pages

439-45

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

X15209, X15749, X15750

External Links

PubMed source DOI: 10.1038/339439a0 View journal details

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Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor.

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