The effect of trifluoperazine on muscle tension and cytoplasmic Ca2+ level in guinea pig ileum.

Japanese journal of pharmacology ·Vol. 49 ·No. 4 ·1989-04-00 ·Pages 540-3

Hori M, Shimizu K, Nakajyo S, Urakawa N

Abstract

In guinea pig ileal muscle strips, trifluoperazine (TFP) inhibited the high K+-induced contraction with an IC50 of 1.9 microM and the Ca2+-induced contraction in skinned fiber with an IC50 of 44 microM. TFP decreased the high K+-induced increase in cytoplasmic Ca2+ level at the concentration 3 microM, which did not inhibit the contraction in skinned fiber. It is suggested that the inhibitory effect of TFP on the high K+-induced contraction is mainly due to the decrease in cytoplasmic Ca2+.

MeSH Terms

Animals Calcium/metabolism Cytoplasm/drug effects,metabolism Guinea Pigs Ileum/drug effects,metabolism In Vitro Techniques Male Muscle Contraction/drug effects Muscle, Smooth/drug effects,metabolism Nifedipine/pharmacology Potassium Cyanide/pharmacology Spectrometry, Fluorescence Trifluoperazine/pharmacology

Chemicals

Trifluoperazine Nifedipine Potassium Cyanide Calcium

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Hori M

Department of Veterinary Pharmacology, Nippon Veterinary and Zootechnical College, Tokyo, Japan.

Shimizu K

Nakajyo S

Urakawa N

Article Info

Journal

Japanese journal of pharmacology

Abbr.

Jpn J Pharmacol

ISSN

0021-5198

DOI

10.1254/jjp.49.540

Published

1989-04-00

Pages

540-3

Language

English

Region

Japan

NLM ID

2983305R

Subset

External Links

PubMed source DOI: 10.1254/jjp.49.540

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The effect of trifluoperazine on muscle tension and cytoplasmic Ca2+ level in guinea pig ileum.

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