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题目:: Prophylactic Gynecologic Specimens from Hereditary Cancer Carriers.
作者:: Shaw(Patricia A),Clarke(Blaise A)
状态:: 发布时间2016-05-31 , 更新时间 2016-05-31
期刊:: Surg Pathol Clin
摘要:: Hereditary breast ovarian cancer and Lynch/hereditary nonpolyposis colorectal cancer syndrome account for most hereditary gynecologic cancers. In the absence of effective cancer screening and other preventative strategies, risk-reducing surgery in women who are known to be at genetic risk of BRCA-associated or of Lynch syndrome carcinomas is effective in significantly decreasing the lifetime risk of developing malignancy. Reflex genomic testing of high-grade ovarian cancers and reflex immunohistochemistry in endometrial cancers will lead to greater recognition of germline-associated cancers. Approaches to processing surgical specimens, the recognition and classification of cancer precursor lesions, and differentiation from their mimics are discussed.
语言:: eng
DOI:: 10.1016/j.path.2016.02.002

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