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PMID: 271989 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Molecular evolution of human and rabbit beta-globin mRNAs.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 74 ·No. 12 ·1977-12-00 ·Pages 5618-22

Kafatos FC, Efstratiadis A, Forget BG, Weissman SM

Abstract

The primary structures of human and rabbit beta-globin mRNAs are compared. Using as a standard the extent of nucleotide substitutions inferred from the hypervariable amino acid residues of fibrinopeptides A and B, which are thought to change largely by neutral evolution, we show that not all silent mutations in globin mRNA are neutral. The divergence of the sequences is limited in part by the selective usage of synonymous codons. The divergent nucleotides tend to be distributed nonrandomly: in the coding region silent substitutions are most rare in segments that are also deficient in substitutions leading to replacements.

MeSH Terms
Animals Base Sequence Biological Evolution Codon Globins/genetics Humans Mutation Nucleic Acid Conformation RNA, Messenger/genetics Rabbits
Chemicals
Codon RNA, Messenger Globins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Kafatos F C
Efstratiadis A
Forget B G
Weissman S M
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40 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.74.12.5618
Published
1977-12-00
Pages
5618-22
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC431834
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.74.12.5618 PMC Full Text View journal details
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