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题目:: Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.
作者:: Fehringer(Gordon),Kraft(Peter),Pharoah(Paul D),Eeles(Rosalind A),Chatterjee(Nilanjan),Schumacher(Fredrick R),Schildkraut(Joellen M),Lindström(Sara),Brennan(Paul),Bickeböller(Heike),Houlston(Richard S),Landi(Maria Teresa),Caporaso(Neil),Risch(Angela),Amin Al Olama(Ali),Berndt(Sonja I),Giovannucci(Edward L),Grönberg(Henrik),Kote-Jarai(Zsofia),Ma(Jing),Muir(Kenneth),Stampfer(Meir J),Stevens(Victoria L),Wiklund(Fredrik),Willett(Walter C),Goode(Ellen L),Permuth(Jennifer B),Risch(Harvey A),Reid(Brett M),Bezieau(Stephane),Brenner(Hermann),Chan(Andrew T),Chang-Claude(Jenny),Hudson(Thomas J),Kocarnik(Jonathan K),Newcomb(Polly A),Schoen(Robert E),Slattery(Martha L),White(Emily),Adank(Muriel A),Ahsan(Habibul),Aittomäki(Kristiina),Baglietto(Laura),Blomquist(Carl),Canzian(Federico),Czene(Kamila),Dos-Santos-Silva(Isabel),Eliassen(A Heather),Figueroa(Jonine D),Flesch-Janys(Dieter),Fletcher(Olivia),Garcia-Closas(Montserrat),Gaudet(Mia M),Johnson(Nichola),Hall(Per),Hazra(Aditi),Hein(Rebecca),Hofman(Albert),Hopper(John L),Irwanto(Astrid),Johansson(Mattias),Kaaks(Rudolf),Kibriya(Muhammad G),Lichtner(Peter),Liu(Jianjun),Lund(Eiliv),Makalic(Enes),Meindl(Alfons),Müller-Myhsok(Bertram),Muranen(Taru A),Nevanlinna(Heli),Peeters(Petra H),Peto(Julian),Prentice(Ross L),Rahman(Nazneen),Sanchez(Maria Jose),Schmidt(Daniel F),Schmutzler(Rita K),Southey(Melissa C),Tamimi(Rulla),Travis(Ruth C),Turnbull(Clare),Uitterlinden(Andre G),Wang(Zhaoming),Whittemore(Alice S),Yang(Xiaohong R),Zheng(Wei),Buchanan(Daniel D),Casey(Graham),Conti(David V),Edlund(Christopher K),Gallinger(Steven),Haile(Robert W),Jenkins(Mark),Le Marchand(Loïc),Li(Li),Lindor(Noralene M),Schmit(Stephanie L),Thibodeau(Stephen N),Woods(Michael O),Rafnar(Thorunn),Gudmundsson(Julius),Stacey(Simon N),Stefansson(Kari),Sulem(Patrick),Chen(Y Ann),Tyrer(Jonathan P),Christiani(David C),Wei(Yongyue),Shen(Hongbing),Hu(Zhibin),Shu(Xiao-Ou),Shiraishi(Kouya),Takahashi(Atsushi),Bossé(Yohan),Obeidat(Ma'en),Nickle(David),Timens(Wim),Freedman(Matthew L),Li(Qiyuan),Seminara(Daniela),Chanock(Stephen J),Gong(Jian),Peters(Ulrike),Gruber(Stephen B),Amos(Christopher I),Sellers(Thomas A),Easton(Douglas F),Hunter(David J),Haiman(Christopher A),Henderson(Brian E),Hung(Rayjean J),,,,,
状态:: 发布时间2016-09-02 , 更新时间 2016-12-08
期刊:: Cancer Res
摘要:: Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression. Cancer Res; 76(17); 5103-14. ©2016 AACR.
语言:: eng
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