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PMID: 27192565 Published · ppublish English Journal Article Review Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation.

Immunity ·Vol. 44 ·No. 5 ·2016-00-17 ·Pages 989-1004

Anderson AC, Joller N, Kuchroo VK

Abstract

Co-inhibitory receptors, such as CTLA-4 and PD-1, have an important role in regulating T cell responses and have proven to be effective targets in the setting of chronic diseases where constitutive co-inhibitory receptor expression on T cells dampens effector T cell responses. Unfortunately, many patients still fail to respond to therapies that target CTLA-4 and PD-1. The next wave of co-inhibitory receptor targets that are being explored in clinical trials include Lag-3, Tim-3, and TIGIT. These receptors, although they belong to the same class of receptors as PD-1 and CTLA-4, exhibit unique functions, especially at tissue sites where they regulate distinct aspects of immunity. Increased understanding of the specialized functions of these receptors will inform the rational application of therapies that target these receptors to the clinic.

MeSH Terms
Animals Antigens, CD/metabolism CTLA-4 Antigen/metabolism Hepatitis A Virus Cellular Receptor 2/metabolism Humans Immune Tolerance Lymphocyte Activation Programmed Cell Death 1 Receptor/metabolism Receptor Cross-Talk Receptors, Immunologic/metabolism Signal Transduction T-Lymphocytes/immunology
Chemicals
Antigens, CD CD223 antigen CTLA-4 Antigen HAVCR2 protein, human Hepatitis A Virus Cellular Receptor 2 Programmed Cell Death 1 Receptor Receptors, Immunologic TIGIT protein, human
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Anderson Ana C
Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Joller Nicole
Institute of Experimental Immunology, University of Zürich, Zürich 8057, Switzerland.
Kuchroo Vijay K
Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: vkuchroo@evergrande.hms.harvard.edu.
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Article Info
Journal
Immunity
Abbr.
Immunity
ISSN
1097-4180
DOI
10.1016/j.immuni.2016.05.001
Email
vkuchroo@evergrande.hms.harvard.edu
Published
2016-00-17
Pages
989-1004
Language
English
Region
United States
NLM ID
9432918
PMCID
PMC4942846
Subset
IM
Grants
NIAID NIH HHS · P01 AI056299 · United States
NINDS NIH HHS · R01 NS045937 · United States
NCI NIH HHS · R01 CA187975 · United States
NINDS NIH HHS · P01 NS076410 · United States
NIAID NIH HHS · P01 AI039671 · United States
NIAID NIH HHS · P01 AI073748 · United States
External Links
PubMed source DOI: 10.1016/j.immuni.2016.05.001 PMC Full Text View journal details
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