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题目:: TGF-β and IL-21 cooperatively stimulate activated CD8(+) T cells to differentiate into Tc17 cells.
作者:: Chen(Hsin-Wei),Tsai(Jy-Ping),Yao(Tsung-You),Hsieh(Chia-Ling),Chen(I-Hua),Liu(Shin-Jen)
状态:: 发布时间2016-05-17 , 更新时间 2016-05-17
期刊:: Immunol Lett
摘要:: TGF-β together with IL-21 or IL-6 can drive the differentiation of naïve CD8(+) T cells into IL-17-producing CD8(+) T cells. These IL-17-producing CD8(+) T cells are termed Tc17 cells. Tc17 cells preserve plasticity under various conditions in vitro and in vivo. IFN-γ-producing CD8(+) T cells are termed Tc1 cells. However, Tc1 cells are considered relatively stable. In the present study, we show that the combination of TGF-β plus IL-21, but not IL-6, converts Tc1 cells into Tc17 cells; this conversion is associated with elevated RORα, RORγt, and Batf mRNA levels. These results indicate that Tc1 cells are skewed to the Tc17 cell phenotype under TGF-β plus IL-21-polarizing conditions. Furthermore, IL-6R is expressed on naïve, but not activated, CD8(+) T cells. In contrast, IL-21R is expressed on both naïve and activated CD8(+) T cells. Thus, differential expression profiles of IL-6R and IL-21R on naïve and activated CD8(+) T cells may be one mechanism by which TGF-β plus IL-21, but not IL-6, can drive activated CD8(+) T cells to differentiate into IL-17-producing cells. Taken together, these results provide a novel viewpoint for the plasticity of Tc1 cells.
语言:: eng
DOI:: 10.1016/j.imlet.2016.04.006

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