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PMID: 27081474 Published · epublish English Journal Article

Rituximab efficiently depletes B cells in lung tumors and normal lung tissue.

F1000Research ·Vol. 5 ·2016-00-00 ·Pages 38

Joly-Battaglini A, Hammarström C, Stankovic B, Aamodt H, Stjärne J, Brustugun OT, Helland Å, Øynebråten I, Corthay A

Abstract

Rituximab is a monoclonal antibody that targets the CD20 B-cell-specific antigen and is widely used as therapy for B-cell lymphoma. Since rituximab depletes both malignant and normal B cells, it is increasingly being used to treat various conditions in which normal B cells have a pathogenic role, such as rheumatoid arthritis and multiple sclerosis. It is well-established that rituximab efficiently eliminates B cells in blood, lymph nodes, and spleen. In contrast, the effect of rituximab in non-lymphoid tissues remains poorly documented and is debated. Here, we report a rheumatoid arthritis patient who was treated with rituximab before receiving thoracic surgery for non-small cell lung cancer. Using flow cytometry and immunohistochemistry, we show that rituximab efficiently depleted CD20-positive B cells in a primary lung tumor, in lung-associated lymph nodes, and in normal lung tissue. We conclude that rituximab may be very efficient at depleting normal B cells in the lungs. This property of rituximab may potentially be exploited for the treatment of conditions in which pathogenic B cells reside in the lungs. On the other hand, the clearance of lung B cells may provide an explanation for the rare cases of severe non-infectious pulmonary toxicity of rituximab.

Keywords
B cells depletion lungs lymph node monoclonal antibody non-small cell lung cancer rituximab tumor
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Joly-Battaglini Albane
Tumor Immunology group, Department of Pathology, Oslo University Hospital, Oslo, Norway; Centre for Immune Regulation, University of Oslo, Oslo, Norway.
Hammarström Clara
Department of Pathology, Oslo University Hospital, Oslo, Norway.
Stankovic Branislava
Tumor Immunology group, Department of Pathology, Oslo University Hospital, Oslo, Norway; Centre for Immune Regulation, University of Oslo, Oslo, Norway.
Aamodt Henrik
Tumor Immunology group, Department of Pathology, Oslo University Hospital, Oslo, Norway; Centre for Immune Regulation, University of Oslo, Oslo, Norway; Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway.
Stjärne Johan
Betanien Hospital, Skien, Norway.
Brustugun Odd Terje
Department of Oncology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Helland Åslaug
Department of Oncology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway; Department of Cancer Genetics, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Øynebråten Inger
Tumor Immunology group, Department of Pathology, Oslo University Hospital, Oslo, Norway; Centre for Immune Regulation, University of Oslo, Oslo, Norway.
Corthay Alexandre
Tumor Immunology group, Department of Pathology, Oslo University Hospital, Oslo, Norway; Centre for Immune Regulation, University of Oslo, Oslo, Norway; Department of Biosciences, University of Oslo, Oslo, Norway.
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Article Info
Journal
F1000Research
Abbr.
F1000Res
ISSN
2046-1402
Published
2016-00-00
Epub
2016-00-08
Pages
38
Language
English
Region
England
NLM ID
101594320
PMCID
PMC4813631
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