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题目:: Bob1 limits cellular frequency of T-follicular helper cells.
作者:: Yamashita(Keiji),Kawata(Koji),Matsumiya(Hiroshi),Kamekura(Ryuta),Jitsukawa(Sumito),Nagaya(Tomonori),Ogasawara(Noriko),Takano(Ken-Ichi),Kubo(Terufumi),Kimura(Sachiko),Shigehara(Katsunori),Himi(Tetsuo),Ichimiya(Shingo)
状态:: 发布时间2016-06-10 , 更新时间 2016-11-10
期刊:: Eur J Immunol
摘要:: T follicular helper (Tfh) cells are involved in specific humoral immunity at initial and recall phases. The fact that the transcription repressors B-cell lymphoma-6 and Blimp-1 determine lineages of Tfh cells and other types of effector CD4(+) T cells, respectively, suggests that there are unique mechanisms to establish Tfh-cell identity. In this study, we found that Tfh cells preferentially express the transcriptional coactivator Bob1. Bob1 of Tfh cells was dispensable for the expression of B-cell lymphoma-6 and the functional property of the cells for B cell help. However, upon initial immunization of foreign antigens, the percentages of Tfh cells in Bob1(-/-) mice were much higher than those in wild-type (WT) mice. In addition, expansion of Tfh cells within Bob1(-/-) CD4(+) T cells transferred into WT mice revealed that the high frequency of Tfh cells was caused by a T-cell-intrinsic mechanism. These findings were further supported by the results of in vitro studies demonstrating that Bob1(-/-) Tfh cells had greater proliferative activity in response to stimuli by CD3/CD28 monoclonal antibody and were also refractory to CD3-induced cell death in comparison to WT Tfh cells. These results suggest that Tfh cells harbor a Bob1-related mechanism to restrict numerical frequency against stimulation of TCRs.
语言:: eng
DOI:

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