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题目:: Targeting PI3K Signaling in Cancer: A Cautionary Tale of Two AKTs.
作者:: Fortin(Jérôme),Mak(Tak W)
状态:: 发布时间2016-04-13 , 更新时间 2016-04-13
期刊:: Cancer Cell
摘要:: AKT inhibitors represent promising therapeutics for cancers with PI3K-AKT pathway hyperactivation. In this issue of Cancer Cell, Wang et al. (2016) report the unexpected finding that ablation of AKT signaling in hepatocytes leads to hepatocellular carcinoma and enhances the incidence of lung metastases in a toxin-induced liver cancer model.
语言:: eng
DOI:: 10.1016/j.ccell.2016.03.020

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