GPCR Signaling: β-arrestins Kiss and Remember.

Current biology : CB ·Vol. 26 ·No. 7 ·2016-04-04 ·Pages R285-8

Ranjan R, Gupta P, Shukla AK

Abstract

β-arrestin-dependent activation of the ERK MAP kinase downstream of GPCRs typically originates from internalized receptor-β-arrestin-ERK complexes. A new study now reports that β-arrestin 2 is sufficiently 'primed' after 'kissing' the β1-adrenergic receptor to initiate ERK activation even in the absence of formation of the receptor-β-arrestin-ERK complex and receptor internalization.

MeSH Terms

Animals Arrestins/metabolism Clathrin/metabolism Endocytosis/physiology Humans Mitogen-Activated Protein Kinases/metabolism Receptors, G-Protein-Coupled/metabolism Signal Transduction

Chemicals

Arrestins Clathrin Receptors, G-Protein-Coupled Mitogen-Activated Protein Kinases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Ranjan Ravi

Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.

Gupta Pragya

Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.

Shukla Arun K

Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India. Electronic address: arshukla@iitk.ac.in.

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

1879-0445

DOI

10.1016/j.cub.2016.02.056

arshukla@iitk.ac.in

Published

2016-04-04

Pages

R285-8

Language

English

Region

England

NLM ID

9107782

Subset

Corrections

CommentOn

PMID: 26829388

External Links

PubMed source DOI: 10.1016/j.cub.2016.02.056 View journal details

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GPCR Signaling: β-arrestins Kiss and Remember.

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