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题目:: miR-935 promotes gastric cancer cell proliferation by targeting SOX7.
作者:: Yang(Meng),Cui(Guozhong),Ding(Mingjian),Yang(Wenhua),Liu(Yanqing),Dai(Dianlu),Chen(Liang)
状态:: 发布时间2016-04-05 , 更新时间 2016-04-05
期刊:: Biomed Pharmacother
摘要:: Gastric cancer is the most common cancer in the world, miRNAs have been demonstrated to play critical role in the development and progression of gastric cancer, such as miR-7, miR-217 and miR-335. Here, we found miR-935 was upregulated in gastric cancer tissues and cells. Overexpression of miR-935 promoted cell proliferation and tumorigenesis in vitro determined by MTT analysis, colony formation analysis, BrdU cell proliferation analysis and soft agar growth analysis, knockdown of miR-935 reduced these effects. Tumor suppressor sex-determining region Y-box 7 (SOX7) was the direct target of miR-935, overexpression of miR-935 inhibited SOX7 expression, but promoted the levels CCND1 and C-MYC which promotes cell proliferation and tumorigenesis, knockdown of miR-935 increased SOX7 level, and inhibited CCND1 and C-MYC expression. Synchronous knockdown of miR-935 and SOX7 promoted cell proliferation and tumorigenesis in vitro, confirming miR-935 regulated gastric cancer cell proliferation by inhibiting SOX7. In summary, we found miR-935 contributed to cell proliferation of gastric cancer through targeting SOX7.
语言:: eng
DOI:: 10.1016/j.biopha.2016.01.011

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