| GeneLibs

题目:: Decreased levels of RGS4 in the paraventricular nucleus facilitate GABAergic inhibition during the acute stress response.
作者:: Jung(Soonwoong),Son(Hyeonwi),Lee(Dong Hoon),Roh(Gu Seob),Kang(Sang Soo),Cho(Gyeong Jae),Choi(Wan Sung),Kim(Hyun Joon)
状态:: 发布时间2016-03-16 , 更新时间 2016-03-16
期刊:: Biochem Biophys Res Commun
摘要:: A healthy acute stress response requires both rapid increase and rapid clearance of blood corticosteroids. We previously showed that regulators of G-protein signaling 4 (RGS4), which decreases in the paraventricular nucleus (PVN) during acute stress, forms a complex with the GABAB receptor. In the present study, we show that this decrease in RGS4 levels in the PVN during an acute stress response facilitates the return of blood corticosteroids to basal levels. Moreover, the effect of RGS4 decrease is attenuated by a GABAB receptor antagonist. These results suggest that RGS4 in the PVN regulates blood corticosteroid-related GABAB receptor signaling during the acute stress response.
语言:: eng
DOI:: 10.1016/j.bbrc.2016.02.108

文献库文献相关信息