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题目:: Stem cells versus plasticity in liver and pancreas regeneration.
作者:: Kopp(Janel L),Grompe(Markus),Sander(Maike)
状态:: 发布时间2016-02-25 , 更新时间 2016-02-25
期刊:: Nat Cell Biol
摘要:: Cell replacement in adult organs can be achieved through stem cell differentiation or the replication or transdifferentiation of existing cells. In the adult liver and pancreas, stem cells have been proposed to replace tissue cells, particularly following injury. Here we review how specialized cell types are produced in the adult liver and pancreas. Based on current evidence, we propose that the plasticity of differentiated cells, rather than stem cells, accounts for tissue repair in both organs.
语言:: eng
DOI:: 10.1038/ncb3309

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