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题目:: Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation.
作者:: Ariyachet(Chaiyaboot),Tovaglieri(Alessio),Xiang(Guanjue),Lu(Jiaqi),Shah(Manasvi S),Richmond(Camilla A),Verbeke(Catia),Melton(Douglas A),Stanger(Ben Z),Mooney(David),Shivdasani(Ramesh A),Mahony(Shaun),Xia(Qing),Breault(David T),Zhou(Qiao)
状态:: 发布时间2016-03-05 , 更新时间 2016-10-19
期刊:: Cell Stem Cell
摘要:: The gastrointestinal (GI) epithelium is a highly regenerative tissue with the potential to provide a renewable source of insulin(+) cells after undergoing cellular reprogramming. Here, we show that cells of the antral stomach have a previously unappreciated propensity for conversion into functional insulin-secreting cells. Native antral endocrine cells share a surprising degree of transcriptional similarity with pancreatic β cells, and expression of β cell reprogramming factors in vivo converts antral cells efficiently into insulin(+) cells with close molecular and functional similarity to β cells. Induced GI insulin(+) cells can suppress hyperglycemia in a diabetic mouse model for at least 6 months and regenerate rapidly after ablation. Reprogramming of antral stomach cells assembled into bioengineered mini-organs in vitro yielded transplantable units that also suppressed hyperglycemia in diabetic mice, highlighting the potential for development of engineered stomach tissues as a renewable source of functional β cells for glycemic control.
语言:: eng
DOI:

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