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题目:: [Research advances of K-ras mutation in the prognosis and targeted therapy of gastric cancer].
作者:: Huang(Y),Wei(J),Liu(B R)
状态:: 发布时间2016-02-22 , 更新时间 2016-02-22
期刊:: Zhonghua Zhong Liu Za Zhi
摘要:: K-ras mutations have been described in 30% of human cancers with significantly different mutation frequencies. High K-ras mutation frequency is found in many cancers such as pancreas and lung cancers, whereas, gastric cancer has a relatively low K-ras mutation frequency. In recent years, numerous researches have focused on the K-ras mutation in gastric cancer. This review summarizes the K-ras mutation frequency in gastric cancer, the relationship of K-ras mutation with clinicopathologic features and prognosis of gastric cancer patients, targeted therapy for K-ras mutated gastric cancer, some small-molecular inhibitors of K-ras, and development of targeted therapy drugs for K-ras signaling pathway in gastric cancer.
语言:: chi
DOI:

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