Compacting Chromatin to Ensure Muscle Satellite Cell Quiescence.
作者:
Li(Yuefeng),Dilworth(F Jeffrey)
状态:
发布时间2016-02-06
, 更新时间 2016-02-06
期刊:
Cell Stem Cell
摘要:
Satellite cells comprise a pool of quiescent stem cells that repair muscle damage, but the mechanisms enforcing their quiescence are poorly defined. In this issue of Cell Stem Cell, Boonsanay et al. (2016) show that the histone methyltransferase Suv4-20H1 maintains satellite cell quiescence by promoting a heterochromatic state through transcriptional repression of the myogenic master regulator MyoD.